WebA camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations - Chemical Communications (RSC Publishing) Issue 84, 2024 Previous Article Next Article From the journal: Chemical Communications A camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations † WebFeb 28, 2024 · Camptothecin (CPT) is a pentacyclic quinoline alkaloid drug, which possesses superior antitumor efficacy, antiproliferative effect and apoptosis induction capacity in colon, lung, breast, ovarian, melanoma and other cancers.
A camptothecin prodrug induces mitochondria-mediated apoptosis …
WebIntroduction. Camptothecin (CPT) is a naturally occurring alkaloid with potent antineoplastic activity against a broad spectrum of solid tumors (eg, primary and metastatic colon carcinoma, small cell lung carcinoma, and ovarian, breast, pancreatic, and stomach cancers), which inhibits DNA topoisomerase I. 1 SN38 (7-ethyl-10-hydroxyl … WebDec 15, 2024 · In this study, we report the synthesis and biological evaluation of the β-glucuronidase-reactive albumin-binding prodrug Mal-glu-CPTS0001 (Fig. 2 A) [40].The … how to store garden vegetables for winter
Pharmaceutics Special Issue : Recent Developments and …
WebDec 5, 2024 · The highly toxic payloads, for instance, maytansine, camptothecin derivatives, auristatin, or doxorubicin are recommended to choose in the conjugates. 9 Finally, ... To create a TfR targeted prodrug of DM1, the TfR binding peptide B6 was designed to conjugate with DM1 through the side chain of cysteine at the C-terminus via … WebAug 31, 2024 · We report a camptothecin (CPT) prodrug that was well formulated in solution and rapidly transformed into long-circulating nanocomplexes in vivo for … WebFeb 16, 2024 · The aim of this study was to prepare small-molecule camptothecin (CPT) prodrugs and evaluate their effectiveness in colorectal carcinoma therapy. Prodrug nanoparticles (NPs) were physicochemically characterized and evaluated for their cytotoxicity in human colon cancer (HCT116) cell lines. The antitumor efficacy of the NPs … read with me bible