Ctgf antibodies

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August undefined, 2024

WebAnti-CTGF antibodies significantly reduced skin fibrosis and collagen contents compared with the control group. These results suggest that our anti-CTGF antibodies are capable of blocking the development of skin fibrosis at least partially and these anti-CTGF neutralizing antibodies may be useful as the feasible strategy to treat skin fibrotic ... WebJun 6, 2012 · CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, angiogenesis, myofibroblast activation, and extracellular matrix deposition and remodeling, which together lead to tissue remodeling and fibrosis. It has been reported in the …

Effects of CTGF Blockade on Attenuation and Reversal of ... - PubMed

WebCTGF is a heparin-binding pleiotropic growth factor involved in chondrogenesis and potentially skeletogenesis. CTGF promotes the adhesion of epithelial cells and fibroblasts, stimulates integrin … WebAug 1, 2024 · Background: Radiotherapy is a mainstay for the treatment of lung cancer that can induce pneumonitis or pulmonary fibrosis. The matricellular protein connective tissue growth factor (CTGF) is a central mediator of tissue remodeling. Methods: A radiation-induced mouse model of pulmonary fibrosis was used to determine if transient … graphing kinetic energy worksheet

Recombinant human CTGF protein (ab50044) Abcam

WebThis affinity purified antibody,in conjunction with Biotinylated antibody Human CTGF (AP01150BT) as a detectionantibody, allows the detection of at least 0.2-0.4 ng/well of recombinant Human CTGF. Western blot: To detect Human CTGF this antibody can be used at a concentration of0.1-0.2 μg/mL. WebThe multimodular CTGF has the ability to bind multiple ligands and has numerous effects on development, differentation, and disease. The C-terminal cysteine knot motif contains the HSPG (proteoglycan) and low … WebCTGF Antibodies. The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher ... chirp review book

CTGF (D8Z8U) Rabbit mAb Cell Signaling Technology

WebThis affinity purified antibody,in conjunction with Biotinylated antibody Human CTGF (AP01150BT) as a detectionantibody, allows the detection of at least 0.2-0.4 ng/well of … WebConnective tissue growth factor (CTGF) is a novel cysteine-rich, secreted protein. Recently, we found that inhibition of the endogenous expression of CTGF by its antisense oligonucleotide and antisense RNA suppresses the proliferation and migration of vascular endothelial cells. In the present study … graphing journalWebCtgf Antibody, Anti-CTGF antibody produced in rabbit. Tested Applications: immunohistochemistry 1:20- 1:50, immunofluorescence 1-4μg/mL, immunoblotting None. Sigma-Aldrich Hpa031074. Synonym: Anti-CCN2, Anti-IGFBP8, Anti-connective tissue growth factor, Ctgf Antibody. graphing khan academy

"WebCTGF/CCN2 was detected in immersion fixed paraffin-embedded sections of human kidney array using Goat Anti-Human CTGF/CCN2 C-Terminus Antigen Affinity-purified Polyclonal Antibody (Catalog # AF660) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and ... " - Ctgf antibodies

Ctgf antibodies

The protein-protein interaction between connective tissue …

WebAnti-CTGF antibody (ab125943) at 1 µg/ml + Connective Tissue Growth Factor (CTGF) Recombinant Protein at 0.1 µg Secondary Goat Anti-Rabbit IgG H&L (HRP) at 1/10000 … WebApr 8, 2016 · Purpose To evaluate and model the pharmacokinetic and pharmacodynamic behavior in rats of FG-3019, a human monoclonal antibody targeting connective tissue growth factor (CTGF). Methods FG-3019, human CTGF (rhCTGF), or the N-terminal domain of rhCTGF were administered intravenously to rats and concentrations of these proteins …

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WebRecombinant Mouse CTGF Protein expressed from Escherichia coli (E. coli). Conjugated to His tag.Order Protein ABIN7122479 online. ... Comparison List Basket Phone: +1 877 … WebApr 12, 2024 · The coverslips were incubated with primary antibodies against USP1 (Cell Signaling Technology, Cat# 8033, 1:200) and TAZ (Abcam, ab224239, 1:200) at 4 °C overnight.

WebAnti-CTGF antibody Specifications. Our Abpromise guarantee covers the use of ab50044 in the following tested applications. The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user. Applications. SDS-PAGE. Functional Studies. Form. Lyophilized ... WebCTGF, also known as CCN2, is a member of the CCN family of matricellular proteins. CTGF, a cysteine-rich, matrix-associated, heparin-binding protein, is widely expressed in various human tissues and organs. CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal ...

WebMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val174 of … WebCTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN …

WebCTGF, also known as CCN2 or connective tissue growth factor, is a member of the CCN family of matricellular proteins. CTGF, a cysteine-rich, matrix-associated, heparin-binding protein, is widely expressed in various …

WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the … graphing laplace functionsWebMouse anti Human CTGF antibody recognizes the connective tissue growth factor, also known as CCN2, IGF-binding protein 8, and IGFBP-8. CTGF is a matricellular protein … graphing lab for chemistryWebMouse Monoclonal Anti-CTGF Antibody against Human connective tissue growth factor. Antibody validation: Validated for Immunohistochemistry and Western Blot Support graphing latexWebCTGF/CCN2 was detected in immersion fixed paraffin-embedded sections of human kidney array using Goat Anti-Human CTGF/CCN2 C-Terminus … graphing lemniscatesWebTarget Information. Connective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. graphing library androidWebMar 18, 2024 · CTGF Antibody (L-20): sc-14939. 4.7 (15) Write a review Ask a question. CTGF Antibody (L-20) is a goat polyclonal IgG; 100 µg/ml. epitope mapping within an internal region of CTGF of human origin. Discontinued polyclonal antibody. See … chirp ridgefield ctWebJun 1, 2024 · Antibody. As CTGF is a secreted protein, monoclonal antibodies are an option as blockade agents. The most advanced trials are of treatment with FG-3019/pamrevlumab, a humanized anti-CTGF antibody, which has been tested in the clinic for muscular dystrophy, pancreatic cancer, liver fibrosis, idiopathic pulmonary fibrosis, … chirp reviews