WebThe spatially directed 3-dimensional (3D) remodeling of synthetic materials may be useful to regionally control cell behavior. In this work, we developed a process to synthesize … WebApr 14, 2024 · Furthermore, the platinum-induced DNA crosslinks are repaired by transcription-coupled nucleotide excision repair (TC-NER) and translesion synthesis independently of HR. Thus, defining BRCAness and HRD based on …

(PDF) DNA interstrand crosslink repair and cancer - ResearchGate

WebA proportion of DNA modifications are caused by exogenous agents, both physical (namely ultraviolet sunlight and ionizing radiation) and chemical (such as benzopyrene, alkylating … WebJul 23, 1996 · cis-Diamminedichloroplatinum(II) (cisplatin) is a widely used anticancer drug that binds to and crosslinks DNA. The major DNA adduct of the drug results from … coca cola bottling plant indianapolis history

An improved 4′-aminomethyltrioxsalen-based nucleic acid crosslinker …

Webemanate, and formed by reactions involving sites or groups on existing. macromolecules or by interactions between existing macromolecules. Notes. 1. The small region may be an atom, a group of atoms, or a number of. branch points connected by bonds, groups of atoms, or oligomeric chains. 2. In the majority of cases, a crosslink is a covalent ... WebJan 7, 2005 · DNA interstrand crosslinks are cytotoxic adducts formed naturally and by drugs used in antitumor therapy. Our current knowledge of the cellular responses … WebIntroduction Nucleic acid crosslinkers are important in nucleic acid research and come in many varieties. 1,2 These range from simple molecules such as formaldehyde to inorganic complexes 3 and have been combined with moieties that can preferentially bind to a target DNA sequence. 4 Crosslinkers can covalently bond to nucleotides by reacting with … coca-cola brands going away