WebJul 11, 2024 · National Center for Biotechnology Information WebDilantin (phenytoin sodium injection, USP) is a ready-mixed solution of phenytoin sodium in a vehicle containing 40% propylene glycol and 10% alcohol in water for injection, adjusted to …
Guidelines for phenytoin infusions - PubMed
WebEach mLof solution contains phenytoin sodium 50 mg, propylene glycol 0.4 mL and ethanol absolute 0.1 mL in Water for Injections, adjusted to pH 12 with either sodium hydroxide or hydrochloric acid. Excipient(s) with known effect Alcohol For the full list of excipients, see 6.1 List of excipients. 3. PHARMACEUTICAL FORM WebSome very weak acidic drugs, such as phenytoin and many barbiturates, whose pKa values are greater than 7, are essentially unionized at all pH values. Therefore, for these weak acidic drugs transport is more rapid and independent of pH. Most weak bases are poorly absorbed in the stomach since they are present largely in the ionized form at low pH. great learning.com login
Pharmacokinetic and Pharmacodynamic Considerations in …
WebNov 2, 2015 · Today, older cytochrome P450 (CYP450) enzyme-inducing AEDs such as phenytoin, carbamazepine, and phenobarbital have been largely replaced by newer AEDs with fewer side effects and drug interactions. These and other considerations such as convenience, availability, and cost should be factored in when physicians select AEDs for … Web(PE = phenytoin sodium equivalents) For IM or IV use RX only 2mLSingle Use Vials Sterile. Each vial contains fosphenytoin sodium 150 mg equivalent to 100 mg phenytoin sodium, Tromethamine (TRIS) as a buffer, Hydrochloric Acid or Sodium Hydroxide to adjust the pH to 8.6 to 9, and sufficient Water for Injection. Usual Dosage: 42799 See insert. Note- WebIn comparison with phenytoin preparations, which have a pH value of 11, fosphenytoin, a phosphorylated prodrug of phenytoin, has a pH value of only 8.6, which decreases the risk of cardiovascular and cutaneous side effects. The near-neutral pH value of fosphenytoin allows effective intravenous or intramuscular administration. greatlearning college fest