WebFeb 5, 2024 · Transforming growth factor β (TGFβ) is a pluripotent cytokine and regulates a myriad of biological processes. It has been established that TGFβ potently inhibits skeletal muscle differentiation; however, the molecular mechanism is not clearly defined. Previously, we reported that inhibition of the TGFβ canonical pathway by an inhibitory Smad, Smad7, … WebProduct overview. Phospho-Smad2 (S245/250/255) ELISA Kit (ab279929) is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in human cell lysates. By determining phosphorylated Smad2 protein in your experimental model system, you can verify pathway activation in your cell ...
Transforming growth factor β-induced phosphorylation of Smad3 ... - PNAS
Smads (or SMADs) comprise a family of structurally similar proteins that are the main signal transducers for receptors of the transforming growth factor beta (TGF-B) superfamily, which are critically important for regulating cell development and growth. The abbreviation refers to the homologies to the Caenorhabditis elegans SMA ("small" worm phenotype) and MAD family ("Mothers Against Decapentaplegic") of genes in Drosophila. WebSep 30, 1997 · Drosophila Mad proteins are intracellular signal transducers of decapentaplegic (dpp), the Drosophila transforming growth factor β (TGF-β)/bone morphogenic protein (BMP) homolog. Studies in which the mammalian Smad homologs were transiently overexpressed in cultured cells have implicated Smad2 in TGF-β … duty free shopping allowance
Phospho-Smad2 (Ser465/467) (138D4) Rabbit mAb - Cell …
WebHigh level expression of phosphorylated Smad2 has been associated with poor prognosis in late stage gastric carcinoma. Roles for Smad2 have been described in thymopoiesis and … WebJan 15, 2003 · Together, these data suggest a new level of cross-talk between ATRA and TGF-β, whereby a putative RAR-α–dependent phosphatase activity limits the levels of … WebPhospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb detects endogenous levels of Smad1 and Smad5 only when dually phosphorylated at Ser463 and Ser465 and is also predicted … duty free shop sault ste marie on