Ribonucleotide-diphosphate reductase
WebbRibonucleoside diphosphate reductase (ribonucleotide reductase) catalyzes the reaction. This enzyme is found in all species and tissues. The immediate source of reducing … Webb1.17.4.1 ribonucleoside-diphosphate reductase AGABI1DRAFT113579 (AGABI1DRAFT_113579) DNA repair and recombination proteins [BR:abp03400] Eukaryotic type Other factors with a suspected DNA repair function Modulation of nucleotide pools AGABI1DRAFT113579 (AGABI1DRAFT_113579) BRITE hierarchy: SSDB: Ortholog …
Ribonucleotide-diphosphate reductase
Did you know?
Webb14 aug. 2024 · 2.1. HGF and Epidermal Growth Factor (EGF) Enhances the Antineoplastic Effect of 5-FU. The proliferative activity of HepG2 cells was marginally increased (though not statistically significant) after treatment with either HGF or EGF for 24 h (Figure 1 F).We observed that 5-FU decreased the proliferative activity in a concentration dependent … WebbRibonucleotide reductase inhibitors are a class of drugs that act by blocking an enzyme called ribonucleotide reductase. They are mainly used as anticancer agents that target DNA synthesis and cell growth. Ribonucleotide reductase inhibitors include drugs like hydroxyurea, fludarabine phosphate, and gemcitabine.
WebbBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. Volume 1851, Issue 9, September 2015, Pages 1240-1253. Disruption of the mevalonate pathway induces dNTP depletion and DNA damage Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase (rNDP), is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. It catalyzes this formation by removing the 2'-hydroxyl group of the ribose ring of nucleoside diphosphates. This reduction … Visa mer Ribonucleotide reductases are divided into three classes. Class I RNR enzymes are constructed from large alpha subunit and small beta subunits which associate to form an active heterodimeric tetramer. By reducing NDPs to 2' … Visa mer Class I RNR comprises RNR1 and RNR2 subunits, which can associate to form a heterodimeric tetramer. RNR1 contains both allosteric sites, mediating regulation of substrate specificity and activity. Depending on the allosteric configuration, one of the four … Visa mer • Ribonucleotide+reductases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • The ribonucleotide reductase database (RNRdb) Visa mer The enzyme ribonucleotide reductase (RNR) catalyzes the de novo synthesis of dNDPs. Catalysis of ribonucleoside 5’-diphosphates (NDPs) involves a reduction at the 2’-carbon of ribose 5-phosphate to form the 2’-deoxy derivative-reduced 2’-deoxyribonucleoside … Visa mer The mechanism that is currently accepted for the reduction of ribonucleotides to deoxyribonucleotides is depicted in the following scheme. … Visa mer Generally Class I RNR inhibitors can be divided in three main groups: translation inhibitors, which block the synthesis of the enzyme; dimerization inhibitors that prevent the association of the two RNR subunits (R1 and R2); and catalytic inhibitors that … Visa mer
WebbRibonucleotide reductase Gene names Name NRDA Organism names Organism Enterobacteria phage T4 (Bacteriophage T4) Taxonomic identifier 10665 NCBI … WebbRibonucleotide-diphosphate reductase subunit beta (RNR) is one of the crucial target proteins of the bacterial pathogens essential in the synthesis of deoxyribonucleotides. Our current study primarily focuses on modeling the …
WebbRefSeq Summary (NM_001165931): This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion.
Webb11 feb. 2024 · The core of these proposed COR biosynthetic pathways can be summarized as follows: AMP was converted to ADP catalyzed by ADEK and ADP was converted to 3′-dADP (3′-deoxyadenosine 5′-diphosphate) catalyzed by ribonucleotide reductase (NRDJ), then 3′-dADP was converted to 3′-deoxyadenosine 5′-phosphate (3′-dAMP) catalyzed by … frozen days 2005WebbRibonucleoside-triphosphate reductase (EC 1.17.4.2, ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase) is an enzyme … frozen dbzWebb9 mars 2024 · ribonucleoside-diphosphate reductase 1 subunit alpha. GeneRIFs: Gene References Into Functions. Elevated Levels of the Escherichia coli nrdAB-Encoded … frozen date